Scott Pilgrim

This is, pretty much, the most perfect comic ever written. Scott's a chipper, friendly, uninhibited hipster with a bunch of hipster friends. The plot revolves (with frequent digressions) around his gleeful romance with a spunky gal, and his full-throttle battles with her glowering exboyfriends and, on a deeper level, their associated emotional baggage. It's during those battles that HeavyInk's "reality-based" tag for this series becomes somewhat insufficient; Scott lives in a universe prone to sudden fits of cartoonish superpowers. All the mayhem is flavored with an appropriate 8-bit nostalgia -- characters compare themselves to Metroid balls, and name their band "Sex Bomb-omb."
Art style is silly and Japanesey and perfect: every panel is begging to be made into a t-shirt. Dialogue is pert: every character talks like they're auditioning for Joss Whedon.
I've lost count of the number of copies I've purchased to give away as gifts.